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Khan, Arshad Bashir
- Formulation and Evaluation of Hydrodynamically Balanced Tablets of Ranitidine Hydrochloride
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Authors
Affiliations
1 Department of Pharmaceutics, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Bangalore - 560035, IN
1 Department of Pharmaceutics, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Bangalore - 560035, IN
Source
Journal of Pharmaceutical Research, Vol 15, No 1 (2016), Pagination: 10-14Abstract
Purpose: The formulation and evaluation of hydrodynamically balanced tablets of ranitidine hydrochloride for gastric drug delivery was the specific aim of this research. Method: The hydrodynamically balanced tablets were prepared by direct compression technique with different ratios of polymers like hydroxyproylmethyl cellulose (HPMC K 4M), Ethyl cellulose, Xanthan gum and Guar gum. The prepared tablets were evaluated for their weight variation, hardness, drug content, friability, floating lag time, floating duration, in vitro dissolution and accelerated stability studies at 40°C ± 2°C/75% RH ± 5% for eight weeks. Conclusion: The floating tablets of ranitidine hydrochloride (HCl) were evaluated for physicochemical characteristics like hardness, weight variation, friability, floating lag time and stability studies. The in vitro buoyancy studies, in vitro drug release studies and the results showed that the best formulation. F2 had sustained release up to 98% of ranitidine hydrochloride over a period of 24 h.Keywords
Ranitidine Hydrochloride, Gastric Drug Delivery, Polymer, Hydrodynamically Balanced.Full Text
References
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- Broad Spectrum UVA & UVB Photoprotectants: An Overview
Abstract Views :180 |
PDF Views:69
Authors
Affiliations
1 Department of Quality Assurance, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Varthur Hobli, Bangalore - 560035, KA, IN
1 Department of Quality Assurance, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Varthur Hobli, Bangalore - 560035, KA, IN
Source
Journal of Pharmaceutical Research, Vol 16, No 2 (2017), Pagination: 143-147Abstract
Purpose: Due to the high exposure of our skin to sunlight which mainly comprises of ultraviolet radiation, a harmful effect is manifested on the skin and the integumentary system. Sunscreens are formulated which safeguards the epidermis of the skin from harmful UV radiations by reflecting, absorbing or by dispersion phenomena. This review focuses on the beneficial aspects of sunscreen and also presents a detail exposition about its formulation aspects and evaluation.
Approach: The review introduces sunscreens and its traditional, chronological usage of sunscreen. The formulation and development of sunscreen emphasis on various UVA and UVB photo protectants used and its evaluation parameters is studied.
Findings: Sunscreens are found to show the photo-protecting properties by absorption or by reflecting mechanism, which has a shielding effect towards the skin against harmful radiations.
Conclusion: Sunscreens protects the skin absorbing or reflecting ultraviolet radiations. The application of sunscreens is an efficient method of protecting skin against UV radiations. Hence a sunscreen plays a vital role in protecting the skin from external harmful radiations.
Keywords
SPF, Sunscreen, UVA, UVB Radiations.Full Text
References
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- Sublingual Tablets and the Benefits of the Sublingual Route of Administration
Abstract Views :350 |
PDF Views:83
Authors
Affiliations
1 Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Varthur Hobli, Bangalore - 560035, KA, IN
1 Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Varthur Hobli, Bangalore - 560035, KA, IN
Source
Journal of Pharmaceutical Research, Vol 16, No 3 (2017), Pagination: 257-267Abstract
Purpose: Sublingual drug delivery can be an alternative and better route when compared to oral drug delivery as sublingually administered dosage forms bypass hepatic metabolism. A rapid onset of pharmacological effect is often desired for some drugs, especially those used in the treatment of acute disorders. Sublingual tablets disintegrate rapidly and the small amount of saliva present is usually sufficient for achieving disintegration of the dosage form coupled with better dissolution and increased bioavailability.
Approach: Published articles from PubMed and other standard sources were utilized to review and compile an overview of sublingual tablets and the benefits of the sublingual route of administration.
Findings: Sublingual tablets were found to have better characteristics when compared to conventional dosage forms. Sublingually administered tablets achieved better bioavailability, rapid onset of action and better dissolution properties due to fast disintegration. The addition of super-disintegrants facilitated rapid disintegration and this approach can be used to treat acute disorders or emergency conditions.
Conclusion: Sublingual tablets or any sublingual dosage form can be used to achieve a rapid onset of action, better patient compliance and increased bioavailability. The sublingual route of administration can be used for drugs which undergo extensive first pass metabolism or degradation in the GIT. Drugs administered sublingually tend to have better bioavailability which correlates to dose reduction when compared to conventional oral tablets.
Keywords
Sublingual Tablets, Easy Self-Medication, Fast Disintegration, Increased Bioavailability.Full Text
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- A Brief Review on Sustained Release Matrix Type Drug Delivery System
Abstract Views :311 |
PDF Views:79
Authors
Affiliations
1 Department of Pharmaceutics, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Varthur Hobli, Bangalore - 560035, KA, IN
1 Department of Pharmaceutics, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Varthur Hobli, Bangalore - 560035, KA, IN
Source
Journal of Pharmaceutical Research, Vol 16, No 3 (2017), Pagination: 282-289Abstract
Purpose: A review on sustained release drug delivery using polymer matrix with emphasis on its contemporary usage and future trends.
Approach: An introduction to sustained release drug delivery system (SR DDS), followed by its rationale, advantages, disadvantages, criteria of a drug to be met to formulate sustained release formulations, classification of matrix tablets, classification of polymers, its mechanism and recent advancements.
Finding: Recent studies indicate that sustained delivery for a very long period, in terms of months is possible using suitable polymer matrices. Also, challenging drug candidates such as proteins are now successfully delivered as sustained release dosage forms.
Conclusion: Sustained release DDS, since 1940s has evolved in different types of dosage forms for sustained effect but future scope will be to treat chronic diseases providing sustained effect.
Keywords
Sustained Release, Polymers, Recent Advancements.Full Text
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